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desvenlafaxine will increase the stage or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Watch. Desvenlafaxine inhibits CYP2D6; with bigger desvenlafaxine doses (ie, four hundred mg) decrease the CYP2D6 substrate dose by nearly 50%; no dosage adjustment essential with desvenlafaxine doses 7 consecutive days straight aw